Synthesis, Characterization of Some New 1,3,5-Trisubstituted Pyrazole Derivatives for Their Antifungal Potential

The aim of the study was to develop, synthesis, and characterise a novel 1,3,5-trisubstituted-2-pyrazolines derivative, as well evaluate its antifungal activity. reaction chalcone derivatives with succinic hydrazide in presence pyridine yielded 1,3,5-tri-substituted-2-pyrazolines derivatives. Total 20 compounds has been synthesized characterized by IR, 1HNMR mass spectral analysis. Antifungal activity carried out onfour fungal strains i.e. Saccharomyces cerevisiae, A. Niger, C. Albicans R. Oryzae two different concentration 50 100 µg/ml Agar-diffusion method using Cup-plate method. usual medicine ketoconazole. All 1,3,5-trisubstituted pyrazole (ME1-ME8, CL1-CL8, BR1-BR4) showed medium best action against examined organisms, according data. (Saccharomyces Candida albicans, Oryzae) revealed following order action: CL-4 > BR-4 CL-3 CL-2 ME-3> ME-2> CL-5 CL-6 ME-4 ME-5 ME-6 ME-7 CL-7 CL-8>ME-8 >CL-1 >ME-1 >ME-1. Electronegative groups (Br, Cl, F, NO2) must be present at third fifth positions 1,3,5-pyrazoline ring for significant action. an electronegative group may required bacterial strains, however addition NO2 demonstrated moderate activity, while substitution methyl methoxy reduce BR-1 through class are most active.